The entry trajectory was reconstructed from an altitude of kft through rollout on Runway 17 at EAFB. The anchor epoch utilized was April 13, 13 h 1 m The final reconstructed inertial trajectory for this flight is BT13M23 under user catalog N. Trajectory reconstruction and Extended BET development are discussed in Section 1 and 2, respectively.
Appendices are attached which present spacecraft and physical constants utilized Appendix A , residuals by station and data type Appendix B , a two second spaced listing of trajectory and air data parameters Appendix C , and input and output source products for archival Appendix D.
Growth of Internet gambling has fuelled concerns about its contribution to gambling problems. However, most online gamblers also gamble on land-based forms, which may be the source of problems for some. Studies therefore need to identify the problematic mode of gambling online or offline to identify those with an online gambling problem. Identifying most problematic form of online gambling e. This study pursued this approach, aiming to: 1 determine demographic, behavioral and psychological risk factors for gambling problems on online EGMs, online sports betting and online race betting ; 2 compare the characteristics of problematic online gamblers on each of these online forms.
An online survey of 4, Australian gamblers measured gambling behavior, most problematic mode and form of gambling, gambling attitudes, psychological distress, substance use, help-seeking, demographics and problem gambling status. Risk factors for online EGM gambling were: more frequent play on online EGMs, substance use when gambling, and higher psychological distress. Risk factors for online sports betting were being male, younger, lower income, born outside of Australia, speaking a language other than English, more frequent sports betting , higher psychological distress, and more negative attitudes toward gambling.
Risk factors for. Sports betting : can gamblers beat randomness? Although skills are not considered relevant in chance-governed activities, only a few studies have assessed the extent to which sport expert skills in wagering are a manifestation of the illusion of control. This study examined a whether expert hockey bettors could make better predictions than chance, b whether expert hockey bettors could achieve greater monetary gains than chance, and c what kind of strategies hockey gamblers rely on when betting.
Accordingly, 30 participants were asked to report their state lottery hockey bets on 6 occasions. We suggest that the information used by bettors, along with near-misses, reinforces their perception of expertise. The results of this experiment suggest that the so-called "skills" of the sports bettors are cognitive distortions.
Effects of expertise on football betting. Football soccer is one of the most popular sports in the world, including Europe. It is associated with important betting activities. A common belief, widely spread among those who participate in gambling activities, is that knowledge and expertise on football lead to better prediction skills for match outcomes. If unfounded, however, this belief should be considered as a form of "illusion of control. Two hundred and fifty-eight persons took part in the study: Logistic regressions were carried out to assess the link between the accuracy of the forecasted scores and the expertise of the participants expert, amateur, layperson , controlling for age and gender.
Expertise, age, and gender did not appear to have an impact on the accuracy of the football match prognoses. Therefore, the belief that football expertise improves betting skills is no more than a cognitive distortion called the "illusion of control.
Public health policies may need to consider the phenomenon in order to prevent problem gambling related to football betting. Using bets to reveal people's opinions on climate change. A long-standing means of revealing people's actual preferences, for example regarding economic and political issues, involves gambles and bets. People tend to place bets when they are confident of their opinions, and they tend to avoid them when they are not confident of their opinions.
We survey the reluctance of climate contrarians to engage in bets with scientists, and we review the historical and likely future fate of various bets on climate change. We show that for the last few decades, most bets placed on the climate would have been lost by contrarians and would have been won by people who endorse the mainstream scientific position.
We relate bets and gambles to actuarial information on climate change and propose ways in which the scientific community can use markets of bets as a tool to resolve ambiguities and to communicate scientific facts with an appropriate level of certainty to the public. Bet -hedging applications for conservation. One of the early tenets of conservation biology is that population viability is enhanced by maintaining multiple populations of a species.
The strength of this tenet is justified by principles of bet -hedging. Management strategies that reduce variance in population size will also reduce risk of extinction. Asynchrony in population fluctuations in independent populations reduces variance in the aggregate of populations whereas environmental correlation among areas increases the risk that all populations will go extinct. We review the theoretical rationale of bet -hedging and suggest applications for conservation management of least terns in Nebraska and grizzly bears in the northern Rocky Mountains of the United States.
The risk of extinction for least terns will be reduced if we can sustain the small central Platte River population in addition to the larger population on the lower Platte. BET bromodomain proteins are required for glioblastoma cell proliferation. Epigenetic proteins have recently emerged as novel anticancer targets. Among these, bromodomain and extra terminal domain BET proteins recognize lysine-acetylated histones, thereby regulating gene expression.
These findings prompted us to determine whether BET proteins may be therapeutic targets in the most common primary adult brain tumor, glioblastoma GBM. We performed NanoString analysis of GBM tumor samples and controls to identify novel therapeutic targets. Lastly, we performed xenograft experiments to determine the efficacy of I- BET in vivo. Disruption of BRD4 expression in glioblastoma cells reduced cell cycle progression. BET inhibitors in cancer therapeutics: a patent review.
Inhibition of Bromodomain and Extra Terminal BET proteins is an emerging approach for developing advanced cancer therapeutics. In , at least thirty patents have been published for developing cancer chemotherapeutics by targeting BET. Currently there are seven small molecule BET inhibitors in various stages of clinical trials for the development of anti-cancer drugs.
Important patents focusing on development of BET inhibitors as potential cancer therapeutics published in have been covered. The reports are presented together with a review of the related structural chemical space. This review mainly focuses on the therapeutic applications, chemical class and structural modifications along with the molecules currently in clinical trials.
BET sub-family proteins are one of the emerging targets to develop anti-cancer agents. Although many research groups have demonstrated the rationality of BET inhibition to combat cancer, a detailed molecular study needs to be performed to investigate the affected biological pathways. In-silico molecular modelling studies can also provide valuable information for designing selective BET inhibitors towards anti-cancer drug discovery and development.
The program provides nationwide educational access to space for Kindergarten through University level students. The SEM program focuses on the science of zero-gravity and microgravity. Student experiment modules are flown in a "carrier" which resides in the cargo bay of the Space Shuttle. The carrier supplies power to, and the means to control and collect data from each experiment. TVA duty, in any gambling activity including the operation of a gambling device, in conducting a An employee shall not participate, while on Government-owned or leased property or while on duty for the Government, in any gambling activity including the operation of Summary results are also included.
The anchor epoch utilized for the trajectory reconstruction was 53, Greenwich Mean Time GMT seconds which corresponds to an altitude at epoch of approximately kft. These data were evaluated based on Space Shuttle-derived considerations as well as model comparisons.
The Aerodynamic BET includes configuration information, final mass properties, and both flight-determined and predicted aerodynamic performance estimates. The predicted data were based on the final pre-operational databook, updated to include flight determined incrementals based on an earlier ensemble of flights. Aerodynamic performance comparisons are presented and correlated versus statistical results based on twenty-two previous missions. BET proteins have recently become recognized for their role in a broad range of cancers and are defined by the presence of two acetyl-histone reading bromodomains and an ET domain.
BRD4 is the most-studied BET protein in cancer, and normally serves as an epigenetic reader that links active chromatin marks to transcriptional elongation through activation of RNA polymerase II. BET inhibitors are acetyl-histone mimetics that specifically bind BET bromodomains, competitively inhibiting its engagement with chromatin. The antineoplastic effects of BET inhibitors were first demonstrated in NMC and have since been shown to be effective at inhibiting the growth of many different cancers, particularly acute leukemia.
Many clinical trials enrolling patients with hematologic and solid tumors are ongoing, with encouraging preliminary findings. Toxicity and resistance may be overcome by combining BET inhibitors with other targeted inhibitors, or through the use of novel BET inhibitor derivatives. Heuristic and analytic processing in online sports betting. This article presents the results of two studies that examine the occurrence of heuristic i.
The first study was qualitative and was conducted with a convenience sample of 12 regular online sports gamblers who described the processes by which they arrive at a sports betting decision. The results of this study showed that betting online on sports events involves a mix of heuristic and analytic processes. The second study consisted in a survey of online sports gamblers where performance in terms of monetary gains, experience in online sports betting , propensity to collect and analyze relevant information prior to betting , and use of bookmaker odds were measured.
This study showed that heuristic and analytic processes act as mediators of the relationship between experience and performance. The findings stemming of these two studies give some insights into gamblers' modes of thinking and behaviors in an online sports betting context and show the value of the dual mediation process model for research that looks at gambling activities from a judgment and decision making perspective. Zuotai gTso thal is one of the famous drugs containing mercury in Tibetan medicine.
However, little is known about the chemical substance basis of its pharmacodynamics and the intrinsic link of different samples sources so far. Given this, energy dispersive spectrometry of X-ray EDX , scanning electron microscopy SEM , atomic force microscopy AFM , and powder X-ray diffraction XRD were used to assay the elements, micromorphology, and phase composition of nine Zuotai samples from different regions, respectively; the XRD fingerprint features of Zuotai were analyzed by multivariate statistical analysis.
XRD fingerprint analysis indicates that the similarity degrees of nine samples are very high, and the results of multivariate statistical analysis are broadly consistent with sample sources. The present research has revealed the physicochemical characteristics of Zuotai, and it would play a positive role in interpreting this mysterious Tibetan drug. The present research has revealed the physicochemical characteristics of Zuotai , and it would play a positive role in interpreting this mysterious Tibetan drug.
Selective BET bromodomain inhibition as an antifungal therapeutic strategy. Invasive fungal infections cause significant morbidity and mortality among immunocompromised individuals, posing an urgent need for new antifungal therapeutic strategies. Here we investigate a chromatin-interacting module, the bromodomain BD from the BET family of proteins, as a potential antifungal target in Candida albicans, a major human fungal pathogen.
We report small-molecule compounds that inhibit C. Crystal structures of the Bdf1 BDs reveal binding modes for these inhibitors that are sterically incompatible with the human BET -binding pockets. Furthermore, we report a dibenzothiazepinone compound that phenocopies the effects of a Bdf1 BD-inactivating mutation on C. These findings establish BET inhibition as a promising antifungal therapeutic strategy and identify Bdf1 as an antifungal drug target that can be selectively inhibited without antagonizing human BET function.
Pseudomonas aeruginosa uses the quaternary amine choline as a carbon source, osmoprotectant, and macromolecular precursor. The importance of choline in P. The data support a model in which, upon transfer to a choline-based medium, the glycine betaine derived from choline taken up by Bet T1 and Bet T3 promotes subsequent GbdR-mediated cbcXWV induction. Furthermore, growth data indicated that the relative contributions of each transporter varied under different conditions, as Bet T1 and CbcXWV were the primary choline transporters under hypo-osmolar conditions whereas Bet T3 was the major choline transporter under hyperosmolar conditions.
This work represents the first systematic approach to unravel the mechanisms of choline uptake in P. The crystal structure of human BET 3 has been determined to 1. A hydrophobic pocket within BET 3 buries a palmitate bound through a thioester linkage to cysteine Both BET 3 and BET 3 C68S are found in membrane and cytosolic fractions of these cells; in membrane extractions, they behave like tightly membrane-associated proteins.
In a deletion strain, both Bet 3p and Bet 3p C80S rescue cell viability. Thus, palmitoylation is neither required for viability nor sufficient for membrane association of BET 3, which may depend on protein—protein contacts within TRAPP or additional, yet unidentified modifications of BET 3. A conformational change may facilitate palmitoyl extrusion from BET 3 and allow the fatty acid chain to engage in intermolecular hydrophobic interactions. Betting patterns for sports and races: a longitudinal analysis of online wagering in Australia.
Online wagering is increasing in popularity as it is easily accessible through websites which market these services widely. However, few studies have examined online betting based on actual behavioural data. This paper describes the results of an analysis of 2,, bets placed with an Australian online wagering operator over a 1-year period. The majority of bets placed were for a win Sports betting was dominated by ball sports, reflecting popular interest in these events.
More than three-quarters The most popular bets placed to win, had a relatively high rate of losses and lowest average returns, which may reflect less sophisticated betting behaviour. More specific handicap and total bets were placed by fewer customers, but were larger bets with the greatest returns. Similarly, bets placed on less popular sporting events had greater average returns potentially reflecting greater customer sophistication and knowledge raising the possibility of a proportion of bettors being more 'skilled'.
As the first paper to analyze the types of bets placed on events and outcomes the results support the notion that wagering is an entertainment activity, and the majority of customers are motivated by factors other than simply winning money. It is generally assumed that recurrent mutations within a given cancer driver gene elicit similar drug responses.
Cancer genome studies have identified recurrent but divergent missense mutations affecting the substrate-recognition domain of the ubiquitin ligase adaptor SPOP in endometrial and prostate cancers. The therapeutic implications of these mutations remain incompletely understood. Conversely, prostate cancer-specific SPOP mutations resulted in impaired degradation of BETs , promoting their resistance to pharmacologic inhibition.
These results uncover an oncogenomics paradox, whereby mutations mapping to the same domain evoke opposing drug susceptibilities. Specifically, we provide a molecular rationale for the use of BET inhibitors to treat patients with endometrial but not prostate cancer who harbor SPOP mutations. Clin Cancer Res; 22 10 ; Extracting local information from crowds through betting markets.
In this research, a set-up is considered in which users can bet against a forecasting agency to challenge their probabilistic forecasts. From an information theory standpoint, a reward structure is considered that either provides the forecasting agency with better information, paying the successful providers of information for their winning bets , or funds excellent forecasting agencies through users that think they know better.
Especially for local forecasts, the approach may help to diagnose model biases and to identify local predictive information that can be incorporated in the models. The challenges and opportunities for implementing such a system in practice are also discussed.
Delayed bet -hedging resilience strategies under environmental fluctuations. Many biological populations, such as bacterial colonies, have developed through evolution a protection mechanism, called bet hedging, to increase their probability of survival under stressful environmental fluctuation.
In this context, the concept of preadaptation refers to a common type of bet -hedging protection strategy in which a relatively small number of individuals in a population stochastically switch their phenotypes to a dormant metabolic state in which they increase their probability of survival against potential environmental shocks. Hence, if an environmental shock took place at some point in time, preadapted organisms would be better adapted to survive and proliferate once the shock is over.
In many biological populations, the mechanisms of preadaptation and proliferation present delays whose influence in the fitness of the population are not well understood. In this paper, we propose a rigorous mathematical framework to analyze the role of delays in both preadaptation and proliferation mechanisms in the survival of biological populations, with an emphasis on bacterial colonies.
Our theoretical framework allows us to analytically quantify the average growth rate of a bet -hedging bacterial colony with stochastically delayed reactions with arbitrary precision. We verify the accuracy of the proposed method by numerical simulations and conclude that the growth rate of a bet -hedging population shows a nontrivial dependency on their preadaptation and proliferation delays.
Contrary to the current belief, our results show that faster reactions do not, in general, increase the overall fitness of a biological population. Uranium nitrides are among the most promising fuels for Generation IV nuclear reactors, but until now, very little has been known about their thermal stability properties under nonequilibrium conditions.
In this work, thermal decomposition of nitrogen-rich uranium nitride denoted as UN 2-x under ultrahigh-vacuum UHV conditions was investigated by thermal desorption spectroscopy TDS. It has been shown that the nitrogen TDS spectrum consists of two peaks at about and K. Understanding persuasive attributes of sports betting advertisements: A conjoint analysis of selected elements. Background and aims Despite recent growth in sports betting advertising, minimal research has examined the influence of different advertising message attributes on betting attitudes and behaviors.
This study aimed to identify which attributes of sports betting advertisements most engage attention, interest, desire and likelihood of betting among non-problem, low-risk, moderate-risk, and problem gamblers. Methods A novel approach utilizing an experimental design incorporating conjoint analysis examined the effects of: three message formats commentary, on-screen display, and studio crossover ; four appeals neutral, jovial, ease of placing the bet , and sense of urgency ; three types of presenters match presenter, sports betting operator, and attractive non-expert female presenter ; and four bet types traditional, exotic key event, risk-free, and micro- bet.
A professional film company using paid actors produced 20 mock television advertisements simulating typical gambling messages based on the conjoint approach. These were embedded into an online survey of Australian adults. Results The most attention-grabbing attributes were type of presenter and type of bet. The attractive non-expert female presenter gained more attention from all gambler groups than other presenters.
The type of bet was most persuasive in converting attention into likely betting among all gambler groups, with the risk-free bet being much more persuasive than other bet types. Problem gamblers were distinct by their greater attraction to in-play micro- bets.
Discussion and conclusion Given the potential for incentivized bets offering financial inducements and for in-play micro- bets to undermine harm minimization and consumer protection, regulators and wagering operators should reconsider whether these bet types are consistent with their responsible gambling objectives. Betting on impulse, without thoughtful consideration, research or informed decision-making, may cause financial and other harms and lead to the development of gambling problems.
Impulse betting undermines responsible consumption of gambling because it reflects self-regulatory failure, impaired control, unreflective decision-making and betting more than planned. In this paper we define impulse gambling and report on a study that aimed to understand more about the intrinsic characteristics of sports bettors who have a greater tendency to bet on impulse. Specifically, the study aimed to identify behavioural, psychological and socio-demographic predictors of impulse sports betting.
A sample of Australian sports bettors completed an online survey that measured the proportion of their bets placed on impulse both before and during sporting events, as well as bets that were researched and planned in advance.
Impulse betting was common, accounting for nearly one-half of all past-year sports bets by respondents. Over three-quarters of respondents had placed one or more impulse bets in the last year and one in seven respondents had made all of their sports bets on impulse.
More impulsive sports bettors were characterised as having higher trait impulsiveness, higher problem gambling severity, more frequent sports betting and a shorter history of sports betting. They favoured betting on in-match contingencies instead of overall match outcomes.
While health promotion strategies are needed to discourage impulse betting , research into contextual factors that arouse urges to bet would also provide direction for harm minimisation measures that help consumers to resist impulsive betting decisions. Kuzmann, E.
Constant current electrochemical deposition technique was used to obtain quaternary alloys of Sn-Fe-Co-Ni from a gluconate electrolyte, which to date have not been reported in the literature. New quaternary Sn-Fe-Co-Ni alloys were successfully prepared. X-Ray fluorescence XRF was used to determine the element composition.
The crystalline structure was analysed quantitatively using x-ray diffraction XRD. Powders morphology was evaluated using a scanning electron microscope SEM with backscattering detectors, and a field emission scanning electron microscope FESEM. Elemental analysis was performed by energy dispersive x-ray analysis EDS.
The semi-quantitative XRF analysis showed the presence of heavy metal oxides in both cements. The XRD spectra of the two cements reported the presence of dicalcium silicate, tricalcium silicate, tricalcium aluminate, tetracalcium aluminoferrite, bismuth oxide and gypsum. Both powders are formed by particles of different shapes: round, prismatic and oblong. Oblong particles in ProRoot and Aureoseal are rich of bismuth. The strong interest in developing new Portland cement-based endodontic sealers will create materials with increased handling characteristics and physicochemical properties.
To date there was a lack of studies on Aureoseal Plus. Despite that it has distinctive elements that could improve its characteristics, resulting in a good alternative to MTA. No risk, no fun-- betting on sports events costs the gamblers a lot of money and brings excellent profits to those who offer the bets.
Among the people who bet on a regular basis, the proportion of young adults is frighteningly high. We now suggest a concept as part of a basic mathematics course for acquiring the necessary mathematical knowledge…. A lot of people risk money with bets on sport events or other events. Bookkeepers that offer such bets earn a lot of money. We are making a proposal more exactly: a concept for a part of a basic mathematics course for learning mathematics behind the screen internet bets are very popular.
Learners should organize a "sports event"…. Bistability, epigenetics, and bet -hedging in bacteria. Clonal populations of microbial cells often show a high degree of phenotypic variability under homogeneous conditions. Stochastic fluctuations in the cellular components that determine cellular states can cause two distinct subpopulations, a property called bistability.
Phenotypic heterogeneity can be readily obtained by interlinking multiple gene regulatory pathways, effectively resulting in a genetic logic-AND gate. Although switching between states can occur within the cells' lifetime, cells can also pass their cellular state over to the next generation by a mechanism known as epigenetic inheritance and thus perpetuate the phenotypic state. Importantly, heterogeneous populations can demonstrate increased fitness compared with homogeneous populations.
This suggests that microbial cells employ bet -hedging strategies to maximize survival. Here, we discuss the possible roles of interlinked bistable networks, epigenetic inheritance, and bet -hedging in bacteria. Purpose Glioblastoma is refractory to conventional therapies.
The bromodomain and extraterminal domain BET proteins are epigenetic readers that selectively bind to acetylated lysine residues on histone tails. These proteins recently emerged as important therapeutic targets in NUT midline carcinoma and several types of hematopoietic cancers. In this study, the therapeutic potential of a novel BET bromodomain inhibitor, JQ1, was assessed in a panel of genetically heterogeneous glioblastoma samples.
Experimental Design The antineoplastic effects of JQ1 were shown using ex vivo cultures derived from primary glioblastoma xenograft lines and surgical specimens of different genetic background. The in vivo efficacy was assessed in orthotopic glioblastoma tumors.
Results We showed that JQ1 induced marked G1 cell-cycle arrest and apoptosis, which was phenocopied by knockdown of individual BET family members. Unlike the observations in some hematopoietic cancer cell lines, exogenous c-Myc did not significantly protect glioblastoma cells against JQ1.
Furthermore, JQ1 significantly repressed growth of orthotopic glioblastoma tumors. Conclusion Our results suggest potentially broad therapeutic use of BET bromodomain inhibitors for treating genetically diverse glioblastoma tumors. The authors advance the concept that institutional culture is a purposeful framework by which to view SEM 's utility, particularly as a cultural change agent.
Through the connection of seemingly independent functions of performance and behavior, implications emerge that deepen the understanding of the influence of culture on performance outcomes…. Spiltoir, Jessica I. Cardiac hypertrophy is an independent predictor of adverse outcomes in patients with heart failure, and thus represents an attractive target for novel therapeutic intervention.
JQ1, a small molecule inhibitor of bromodomain and extraterminal BET acetyl-lysine reader proteins, was identified in a high throughput screen designed to discover novel small molecule regulators of cardiomyocyte hypertrophy. JQ1 dose-dependently blocked agonist-dependent hypertrophy of cultured neonatal rat ventricular myocytes NRVMs and reversed the prototypical gene program associated with pathological cardiac hypertrophy.
JQ1 also blocked left ventricular hypertrophy LVH and improved cardiac function in adult mice subjected to transverse aortic constriction TAC. BRD4 protein expression was increased during cardiac hypertrophy, and hypertrophic stimuli promoted recruitment of BRD4 to the transcriptional start site TSS of the gene encoding atrial natriuretic factor ANF.
These findings define a novel function for BET proteins as signal-responsive regulators of cardiac hypertrophy, and suggest that small molecule inhibitors of these epigenetic reader proteins have potential as therapeutics for heart failure. Nitration of the Pollen Allergen Bet v 1. Nitration of pollen derived allergens can occur by NO2 and ozone in polluted air and it has already been shown that nitrated major birch Betula verrucosa pollen allergen Bet v 1.
However, the mechanisms by which nitration might contribute to the induction of allergy are still unknown. In this study, we assessed the effect of chemically induced nitration of Bet v 1 on the generation of HLA-DR associated peptides. Human dendritic cells were loaded with unmodified Bet v 1 or nitrated Bet v 1, and the naturally processed HLA-DR associated peptides were subsequently identified by liquid chromatography-mass spectrometry. Both the copy number of Bet v 1 derived peptides as well as the number of nested clusters was increased.
Our study shows that nitration of Bet v 1 alters antigen processing and presentation via HLA-DR, by enhancing both the quality and the quantity of the Bet v 1-specific peptide repertoire. These findings indicate that air pollution can contribute to allergic diseases and might also shed light on the analogous events concerning the nitration of self-proteins.
Metal-organic frameworks MOFs can exhibit exceptionally high surface areas, which are experimentally estimated by applying the BET theory to measured nitrogen isotherms. Recent emphasis has been placed on the usage of four so-called " BET consistency criteria. Analysis of simulation snapshots elucidated the contributions of "pore-filling" and "monolayer-formation" to the nitrogen adsorption loadings in different MOF pores, revealing the origin of inaccuracies in BET -calculated monolayer loadings, which largely explain discrepancies between BET areas and NASAs.
While it is not always possible to satisfy all consistency criteria, it is critical to minimize the deviation from these criteria during BET range selection to consistently compare BET areas of different MOFs and for comparing simulated and experimental BET areas of a given MOF. An increase in Mn content mostly leads to an increase in the number of Mn cations in the structure of solid solutions; however, a part of the manganese cations form Mn2O3 and Mn3O4 in the crystalline and amorphous states.
Framework for SEM contour analysis. SEM images provide valuable information about patterning capability. However, there is currently a shortage of appropriate metrology tools to inspect complex two-dimensional patterns in the same way as one would work with simple one-dimensional patterns. In this article we present a full framework for the analysis of SEM images.
It has been proven to be fast, reliable and robust for every type of structure, and particularly for two-dimensional structures. To achieve this result, several innovative solutions have been developed and will be presented in the following pages. Firstly, we will present a new noise filter which is used to reduce noise on SEM images, followed by an efficient topography identifier, and finally we will describe the use of a topological skeleton as a measurement tool that can extend CD measurements on all kinds of patterns.
The crystallinity index CI is a measure of the percentage of crystalline material in a given sample and it is also correlated to the degree of order within the crystals. In the literature two ways are reported to measure the CI: X-ray diffraction and infrared spectroscopy. Although the CI determined by these techniques has been adopted in the field of archeology as a structural order measure in the bone with the idea that it can help e.
To investigate similarities and differences between the two techniques, the CI of sound human tooth enamel and synthetic hydroxyapatite HAP was measured in this work by X-ray diffraction XRD and Fourier Transform Infrared spectroscopy FTIR , at room temperature and after heat treatment. Although the CI XRD index is related to the crystal structure of the samples and the CI FTIR index is related to the vibration modes of the molecular bonds, both indices showed similar qualitative behavior for heat-treated samples.
Their diffraction patterns were clustered analysis and evaluated their similarity degree. Established the analytical method of Dens Draconis and Os Draconis basing the features fingerprint information of the 10 common peaks by XRD pattern.
The similarity degree of separate sources of Dens Draconis was high,while the similarity degree of separate sources of Os Draconis was significant different from each other. This method can be used for identification and evaluation of Os Draconis and Dens Draconis. It also can be used for identification the counterfeit of Os Draconis effectively. Extended Data Fig. Extending the translational significance of these findings, we evalu - ated the ability of JQ1 to inhibit tumour.
Bet v 6, a minor birch pollen allergen, is commercially available for allergen-specific IgE antibody testing. However, there is hardly any literature on the clinical impact of Bet v 6. The aim of the present study was to analyze if testing specific IgE against Bet v 6 can add valuable benefit to the standard diagnostics of birch pollen-sensitized patients, especially in patients with unknown sensitization-eliciting allergens.
Birch pollen-sensitized patients with missing IgE reactivity against Bet v 1, 2, and 4 were tested for specific IgE antibodies against Bet v 6. For comparison, an equal number of randomly selected patients with birch pollen sensitization, regardless of their individual sensitization patterns, were tested for specific anti- Bet v 6. Of 57 cases with missing reactivity against the standard birch pollen allergens, 2 patients were positive for Bet v 6.
None of the Bet v 6-positive patients showed allergic symptoms after exposure to birch pollen or an oral allergy syndrome. An increased prevalence of asthma and a higher degree of sensitization were the only distinctive clinical features in Bet v 6-positive patients. Among birch pollen-sensitized patients, the prevalence of specific IgE against Bet v 6 is low. Further, sensitization to Bet v 6, which shows characteristics of a panallergen, remains clinically silent.
Therefore, determination of anti- Bet v 6 is not considered useful in the clinical routine. Karger AG, Basel. When faced with a variable environment, organisms may switch between different strategies according to some probabilistic rule. In an infinite population, evolution is expected to favor the rule that maximizes geometric mean fitness. If some environments are encountered only rarely, selection may not be strong enough for optimal switching probabilities to evolve.
Here we calculate the evolution of switching probabilities in a finite population by analyzing fixation probabilities of alleles specifying switching rules. We consider a simplified model in which environmental switching and phenotypic switching are one-way processes, and mutation is symmetric and rare with respect to the timescale of fixation events. Schmidtlein, C. We also investigated a similar system using an LaBr3 scintillator corresponding to 22 kg and 9 kg for the 25 mm and 10 mm thick systems assuming an LaBr3 density of 5.
Background and aims Marketing inducements for addictive products, such as wagering, can prompt impulse purchasing by triggering consumption reminders, urges, and cravings. Wagering inducements incentivize betting by providing bonus bets , money-back guarantees, deposits into betting accounts, and discounts. Their promotion during sporting events, push marketing efforts directed at consumers, and ease of uptake at the point-of-sale, may trigger betting on impulse.
This study examined whether the uptake of wagering inducements predicted impulse betting on sport. Results More frequent users of wagering inducements had a greater tendency to place impulse in-play bets , which were also predicted by problem gambling, higher buying impulsiveness, higher frequency of watching sports, younger age, and higher educational status. Sports bettors with a greater tendency to place impulse bets before match commencement also tended to have higher buying impulsiveness and to be younger, but they used inducements less frequently, and tended to be female, less-educated and non-problem, moderate risk, or problem gamblers.
Discussion and conclusions Uptake of wagering inducements appeared to be particularly effective in stimulating impulse in-play betting among problem gamblers and frequent sports viewers. These results suggest that a more cautious approach to the regulation of both in-play bets and wagering inducements may be required to better protect young adults from gambling problems and harm.
Correlation of sensitizing capacity and T-cell recognition within the Bet v 1 family. Background Bet v 1 is the main sensitizing allergen in birch pollen. Like many other major allergens, it contains an immunodominant T cell—activating region Bet v Api g 1, the Bet v 1 homolog in celery, lacks the ability to sensitize and is devoid of major T-cell epitopes.
Objective We analyzed the T-cell epitopes of Mal d 1, the nonsensitizing Bet v 1 homolog in apple, and assessed possible differences in uptake and antigen processing of Bet v 1, Api g 1, and Mal d 1. Methods For epitope mapping, Mal d 1—specific T-cell lines were stimulated with overlapping synthetic mer peptides.
The surface binding, internalization, and intracellular degradation of Bet v 1, Api g 1, and Mal d 1 by antigen-presenting cells were compared by using flow cytometry. All proteins were digested with endolysosomal extracts, and the resulting peptides were identified by means of mass spectrometry. Results Like Api g 1, Mal d 1 lacked dominant T-cell epitopes.
The degree of surface binding and the kinetics of uptake and endolysosomal degradation of Bet v 1, Api g 1, and Mal d 1 were comparable. Endolysosomal degradation of Bet v 1 and Mal d 1 resulted in very similar fragments. The Bet v and Mal d regions showed no striking difference in their binding affinities to the most frequent HLA-DR alleles.
Conclusion The sensitizing activity of different Bet v 1 homologs correlates with the presence of immunodominant T-cell epitopes. However, the presence of Bet v is not conferred by differential antigen processing. Osmosensor and osmoregulator properties of the betaine carrier Bet P from Corynebacterium glutamicum in proteoliposomes.
The secondary glycine betaine uptake system Bet P of Corynebacterium glutamicum was purified from Escherichia coli membranes in strep-tagged form after heterologous expression of the bet P gene and was reconstituted in E. Bet P was effectively regulated by the external osmolality and was stimulated by the local anesthetic tetracaine. A shift of the optimum of osmotic stimulation to higher osmolalities was linearly correlated with an increasing share of phosphatidyl glycerol, the major lipid of the C.
This finding correlates with results demonstrating an identical shift when bet P was expressed in E. A number of diazepines are known to inhibit bromo- and extra-terminal domain BET proteins. Their BET inhibitory activity derives from the fusion of an acetyl-lysine mimetic heterocycle onto the diazepine framework.
Herein we describe a straightforward, modular synthesis of novel 1,2,3-triazolobenzodiazepines and show that the 1,2,3-triazole acts as an effective acetyl-lysine mimetic heterocycle. Structure-based optimization of this series of compounds led to the development of potent BET bromodomain inhibitors with excellent activity against leukemic cells, concomitant with a reduction in c- MYC expression.
These novel benzodiazepines therefore represent a promising class of therapeutic BET inhibitors. NMR resonance assignments of a hypoallergenic isoform of the major birch pollen allergen Bet v 1. In Northern America and Europe a great number of people are suffering from birch pollen allergy and pollen related food allergies. The trigger for these immunological reactions is the In nature, Bet v 1 occurs as a mixture of various isoforms that possess different immunological properties despite their high sequence identities.
Bet v 1. We assigned the backbone and side chain 1 H, 13 C and 15 N resonances of this protein and predicted its secondary structure. The NMR-chemical shift data indicate that Bet v 1. Our resonance assignments create the foundation for detailed characterization of the dynamic properties of Bet v 1 isoforms by NMR relaxation measurements.
Power-law distribution in Japanese racetrack betting. Gambling is one of the basic economic activities that humans indulge in. An investigation of gambling activities provides deep insights into the economic actions of people and sheds lights on the study of econophysics.
In this paper we present an analysis of the distribution of the final odds of the races organized by the Japan Racing Association. This power-law can be explained on the basis of the assumption that every bettor bets his money on the horse that appears to be the strongest in a race. Here we show effect of the polyamine polymer chain length to BET isotherms.
Folded or Not? Background Recombinant Bet v 1a r Bet v 1a has been used in allergy research for more than three decades, including clinical application of so-called hypoallergens. Quantitative IgE binding to r Bet v 1a depends on its native protein conformation, which might be compromised upon heterologous expression, purification, or mutational engineering of r Bet v 1a. Structural integrities and oligomerisation of the recombinant allergens were evaluated by 1H-nuclear magnetic resonance 1H-NMR , circular dichroism CD spectroscopy, and dynamic light scattering DLS.
Experimental and theoretically expected results of the analyses were compared. The hydrodynamic radii RH of 2. Serum IgE of birch pollen allergic subjects bound to 0. The water adsorption experiments were conducted in an optical cell, at room temperature under the relative humidity RH range of 1.
Besides, the standard adsorption enthalpies of water onto natural mineral dust samples were determined. These results suggest that the hygroscopic properties of investigated African dusts are quite similar over the whole investigated RH range. Furthermore, one of the major conclusions is that under most atmospheric relative humidity conditions, natural mineral samples are always covered with at least one layer of adsorbed water. Nanochitosan was prepared by the ionotropic gelation method and its average particle size has been analyzed using Dynamic Light Scattering DLS method.
FTIR results confirmed the formation of well-blended membranes and the XRD analysis revealed enhanced amorphous nature of the membrane ratio DSC study was conducted to find out the thermal behavior of the blend membranes and the results clearly indicated good thermal stability and single glass transition temperature T g of all the prepared membranes.
Asymmetric nature and rough surface morphology was confirmed using SEM analysis. From the results it was evident that the blending of the polymers with higher concentration of nanochitosan can alter the nature of the resulting membranes to a greater extent and thus amorphous membranes were obtained with good miscibility and compatibility. Exploration of geo-mineral compounds in granite mining soils using XRD pattern data analysis. The purpose of the study was to investigate the major minerals present in granite mining waste and agricultural soils near and away from mining areas.
The mineral exploration of representative sub-soil samples are identified by X-Ray Diffractometer XRD pattern data analysis. However, in case of agricultural farm soils the major minerals are identified as Gypsum, Calcite, Magnetite, Hematite, Muscovite, K-Feldspars and Quartz. Moreover, the agricultural soils neighbouring mining areas, the minerals are found that, the enriched Mica group minerals Lepidolite and Illite the enriched Orthopyroxene group minerals Ferrosilite and Enstatite.
It is observed that the Mica and Orthopyroxene group minerals are present in agricultural farm soils neighbouring mining areas and absent in agricultural farm soils away from mining areas. The study demonstrated that the chemical migration takes place at agricultural farm lands in the vicinity of the granite mining areas. Bromodomain and extraterminal domain BET protein inhibitors are emerging as promising anticancer therapies. The gene encoding the E3 ubiquitin ligase substrate-binding adaptor speckle-type POZ protein SPOP is the most frequently mutated in primary prostate cancer.
In contrast, prostate cancer-associated SPOP mutants show impaired binding to BET proteins, resulting in decreased proteasomal degradation and accumulation of these proteins in prostate cancer cell lines and patient specimens and causing resistance to BET inhibitors. The structure-building phenomena within clay aggregates are governed by forces acting between clay particles.
Measurements of such forces are important to understand in order to manipulate the aggregate structure for applications such as dewatering of mineral processing tailings. A parallel particle orientation is required when conducting XRD investigation on the oriented samples and conduct force measurements acting between basal planes of clay mineral platelets using atomic force microscopy AFM. From these investigations, we conclude that high clay concentrations and larger particle diameters up to 5 microm in suspension result in random orientation of platelets in the substrate.
Conducted AFM investigations show that smectite studied in water based electrolytes show very long-range repulsive forces lower in strength than electrostatic forces from double-layer repulsion. It was suggested that these forces may have structural nature. Smectite surface layers rehydrate in water environment forms surface gel with spongy and cellular texture which cushion approaching AFM probe. This structural effect can be measured in distances larger than nm from substrate surface and when probe penetrate this gel layer, structural linkages are forming between substrate and clay covered probe.
These linkages prevent subsequently smooth detachments of AFM probe on way back when retrieval. This effect of tearing new formed structure apart involves larger adhesion-like forces measured in retrieval. It is also suggested that these effect may be enhanced by the nano-clay particles interaction. FI schedules and persistence at gambling in the U. This study reports on the direct observations of customers in two U. These observations revealed that bets were more frequently placed in the last minutes just prior to the start the OFF , and that this was caused by high-frequency gamblers customers who had eight or more bets in a session consistently placing their bets in the last two minutes prior to the OFF.
It was argued that the betting behavior of the "gamblers" could not be explained either in terms of "skillful betting " or solely in terms of variable ratio schedules but was more adequately accounted for in terms of an interval schedule. To calculate these probabilities, and as such indirectly sports betting odds, several parameters must be take into account.
Firstly, the statistics related to the match will be gathered and taken into consideration by experts. For instance, to determine the odds offered on a tennis match between Rafael Nadal and Novak Djokovic, there are a number of factors which need to be taken into account - the previous results of the players, their performance in the tournament in question, the results of the pairs previous confrontations, even the number of sets they have conceded in previous weeks.
In addition, several more subjective elements must also be considered, such as the real motivation of the players, the stakes and context of the meeting, and possible animosity or rivalry between the two players. From this analysis, you can get quite a complete calculation from the bookmakers to determine the probable winning side - and the same reasoning applies for football odds, basketball odds, and rugby odds. Last but not least, note that the sports betting odds offered by bookies will never be fixed, and may vary as time comes closer to the match in question.
The same reasoning applies after the start of a match during a live bet live odds. Such a factor is not to be underestimated, so be sure to always place your sports bets at the best possible time. See all Bet betting offers! Using an odds calculator based on probability, bookmakers odds can be used to determine the potential winning of a sports bet. The higher the odds, the greater your potential for winnings, which is why it is imperative to always compare bookmakers' odds before betting.
Odds comparison will help you also to discover the best Euro odds. Indeed it is not uncommon that the betting odds on a single match may vary in value between different bookmakers. The value of comparing odds is clear - always take advantage of the best value being offered to expect the greatest winnings - the reason why our Sportytrader odds comparator was created.
Visit Sport to see their new offers! Even if some odds offered abroad may be higher than those of the English market, remember that the sites they are on do not guarantee your security, nor the assurance of being able to withdraw your winnings. Under the Gambling Act , a numbers of regulations have been put in place to protect your interests should you fall victim to a scam such as this, however prevention is better than cure.
It is better to avoid the risk of such a situation altogether, and besides, the UK bookmakers are some of the best in Europe - there is no reason to go elsewhere. Check out exciting bonuses at Betway! Finally, the last tip we can give you is to multiply the number of online bookies you have registered an account with. Surely, what would be the point of using our odds comparator if you do not have an account on the site that offers the best odds on the football, rugby, tennis or basketball match of your choice - Nothing except frustration for you.
To always bet to the best odds on the market for the match of your choice, do not hesitate to open an account with a set of UK bookmakers, which will allow you to win the best possible profits each time you succeed. According to the calculations of our specialists, a difference of a few hundred pounds can be felt over a year by not always taking advantage of the best odds.
You would be wrong to deprive yourself, especially given the nice welcome bonuses currently available on the market. One word of order: always exploit the best odds! Our odds comparator compares all of the sports betting websites available in the UK. You save time! You win more money! Would you like to go on our mobile site for a better experience?
Exclusive offer. Bonus CHF. All the competitions. Betting Tips Odds Live. X competitions and countries Competitions Country. X more competitions. Sports Betting Odds Comparison Want to bet with the best odds? Betting odds explained First and foremost, you have to understand what odds are in the world of online sports betting. Understanding betting odds comparison Using an odds calculator based on probability, bookmakers odds can be used to determine the potential winning of a sports bet.
Outside the Gambling Commission: Why should we avoid it? How to always enjoy the best odds? All odds. Crystal Palace. Manchester City. Aston Villa. West Brom. Manchester United FC. West Ham. Sheffield United FC. Bristol City. Athletic Bilbao. Bayern Munich. Tigres UANL. Saint Etienne. SC Braga. Benfica Lisbon. Celta Vigo. Atletico Madrid. Real Sociedad. Real Madrid. Benevento Calcio. AC Milan. Inter Milano. Hellas Verona. Jahn Regensburg. Werder Bremen.
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Draw 3. Away 2. Home 2. Away 4. RB Leipzig. Home 1. Draw 6. Away Away 3. Holstein Kiel. Wurzburger Kickers. Away 6. Draw 4. Away 7. Away 8. Celta Vigo. Best Betting Bonuses See All. Read Review Claim. Detailed betting statistics fro various sports. Calculated average values and more. Show me more. Finally, the last tip we can give you is to multiply the number of online bookies you have registered an account with. Surely, what would be the point of using our odds comparator if you do not have an account on the site that offers the best odds on the football, rugby, tennis or basketball match of your choice - Nothing except frustration for you.
To always bet to the best odds on the market for the match of your choice, do not hesitate to open an account with a set of UK bookmakers, which will allow you to win the best possible profits each time you succeed. According to the calculations of our specialists, a difference of a few hundred pounds can be felt over a year by not always taking advantage of the best odds. You would be wrong to deprive yourself, especially given the nice welcome bonuses currently available on the market.
One word of order: always exploit the best odds! Our odds comparator compares all of the sports betting websites available in the UK. You save time! You win more money! Would you like to go on our mobile site for a better experience? Exclusive offer.
Bonus CHF. All the competitions. Betting Tips Odds Live. X competitions and countries Competitions Country. X more competitions. Sports Betting Odds Comparison Want to bet with the best odds? Betting odds explained First and foremost, you have to understand what odds are in the world of online sports betting. Understanding betting odds comparison Using an odds calculator based on probability, bookmakers odds can be used to determine the potential winning of a sports bet.
Outside the Gambling Commission: Why should we avoid it? How to always enjoy the best odds? All odds. Crystal Palace. Manchester City. Aston Villa. West Brom. Manchester United FC. West Ham. Sheffield United FC. Bristol City. Athletic Bilbao. Bayern Munich. Tigres UANL. Saint Etienne. SC Braga. Benfica Lisbon. Celta Vigo. Atletico Madrid. Real Sociedad. Real Madrid. Benevento Calcio. AC Milan. Inter Milano. Hellas Verona. Jahn Regensburg.
Werder Bremen. Borussia Dortmund. Rot-Weiss Essen. Holstein Kiel. Herta Berlin. Bayer Leverkusen. Union Berlin. Schalke Eintracht Frankfurt. Arminia Bielefeld. Montpellier Hsc. RC Strasbourg Alsace. Lille Osc. Nacional Madeira. Vitoria Guimarares. Rio Ave. Gil Vicente. Santa Clara. Sporting Lisbon. Pacos Ferreira. Caykur Rizespor. Buyuksehir Belediye Erzurumspor. MKE Ankaragucu. Gaziantep FK. Fatih Karagumruk SK. Goztepe SK. Istanbul Basaksehir FK. Genclerbirligi SK.
Besiktas JK. Antalyaspor AS.
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legal sport betting sites I am a new user I am a returning user. All betting odds comparator ic shown on OddsJet wager, remember that wagering is purposes only. PARAGRAPHUnlike most odds comparison sites left and click the odds wide grids that are very hard to read, OddsJet is designed to work in a manner similar to most online. Amitkansara Have dealed with lots of XML tasks previously. Get paid for your work. In the event listings, OddsJet are for entertainment and informational in a new tab. Then, use the bet slip inputs and controls to view which betting sites offer your best odds and potential returns in descending order for single, combination or multiple bet scenarios sportsbooks the right. The odds and lines shown and bid on jobs. Tip: when clicking, hold Ctrl come from reputable betting sites. I am looking to Hire Work.Find the best betting sites odds for your sports bets with our odds comparison guide. Updated in Real Time, 7 days a week! Compare Bears Academy v Horsens IC odds live on the Betting sites. It's the best way to bet well on Basketligaen (11/14/). Compare Horsens IC v Bakken Bears odds live on the Betting sites. It's the best way to bet well on Basketligaen (01/31/).